It is psychostimulant used for treating depression in patients with a prognosis of < 3 months because they may not live long enough to benefit from conventional antidepressants. A response is achieved in a few days by increasing the dose until benefit or undesirable effects occur.
Well tolerated; no lag time to effect; rapid clearance from the body; improves appetite
Can only be given PO; may precipitate or exacerbate delirium; undesirable effects include restlessness, hallucinations, insomnia, tachycardia and hypertension; tolerance may develop.
Start with 2.5 mg in the morning, increase progressively every 2 days if necessary up to 20 mg in the morning
Psychostimulants. Twycross R, Wilcock A (Ed). Palliative Care Formulary. Third Edition, Palliativedrugs.com Ltd, United Kingdom, 2007, p. 167 - 171.