A mouthwash containing the biguanide chlorhexidine and ethyl alcohol, with topical antibacterial activity.
Upon rinsing the oral cavity with the chlorhexidine/ethyl alcohol mouthwash, the positively charged chlorhexidine cation exerts its antibacterial activity through binding to the negatively charged microbial cell surface, which destroys the integrity of the cell membrane. This causes leakage of intracellular components leading to cell death. Ethyl alcohol denatures bacterial proteins, and dissolves and disrupts the bacterial lipid membrane, thereby killing the bacteria. This reduces oral colonization with harmful bacteria and may prevent oral mucositis.
Adult, mouth/throat oral hygiene.
Gingivitis - 0.2% soln - rinse w/ 10 mL for about 1 min bid. As spray: apply bid. Max: 12 actuations bid. As gel: brush teeth w/ 1 inch of gel once or bid for about 1 min.
Adverse drug reactions: skin sensitivity; irritation of conjunctiva, mucosal irritation; reversible brown staining of the teeth; tongue discoloration and burning sensation; transient taste disturbance; parotid gland swelling.