It is 25-50 times more potent than morphine; about 0.4 mg buprenorphine is equianalgesic with 10 mg morphine given intramuscularly .
Because buprenorphine is a partial μ-opioid receptors agonist, it may cause symptoms of abstinence in patients who have been receiving receptor agonists for several weeks.
Buprenorphine is relatively well absorbed by most route; it comes in many forms including SL tablets, ampules for SC, IM and IV injection, and transdermal patches.
Sublingual: moderate to severe pain 200-400 mcg 6-8 hrly.
IV: perioperative analgesia 300-450 mcg via slow inj.
IV/IM: moderate to severe pain 300-600 mcg 6-8 hrly.
Adverse drug reactions
: cardiovascular and other side effects (e.g, sedation, nausea, vomiting dizziness, sweating and headache) appear to be similar to those of morphine-like opioids.
Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.