is a corticosteroid that has mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein syntheis, decreasing the migration of polymorphonuclear leucocytes/fibroblasts and reversing capillary permeability.
is a selective β2-adrenergic agonist. It causes bronchodilation by catalysing the conversion of adenosine triphosphate to cyclic-3', 5'-adenosine monophosphate (cyclic AMP) resulting in bronchial smooth muscle relaxation.
Asthma; chronic obstructive pulmonary disease
As combination preparations in 2 strengths: per inhalation containing (budesonide(mcg)/formoterol fumarate(mcg)): 80/4.5 or 160/4.5: 2 inhalations bid. Patients who are receiving low-medium dose inhaled corticosteroid may be started on lower strength combination while those receiving medium-high dose inhaled corticosteroid may be started on higher strength combination. Patients who are not adequately controlled on the lower strength combination may convert to the higher strength combination after 1-2 wk of treatment. Not to use more than 4 inhalations/day of either strength.
Adverse drug reaction
s: headache, nasopharyngitis, upper respiratory tract infections, stomach discomfort, vomiting, oral candidiasis, back pain, nasal congestion, sinusitis.
Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.