It is a corticosteroid ester with marked topical effect; this property is made use of in bronchial inhalation.
It controls the rate of protein synthesis, depresses the migration of polymorphonuclear leukocytes, fibroblasts, reverses capillary permeability and lysosomal stabilisation at the cellular level to prevent or control inflammation.
Corticosteroid-responsive dermatoses - 0.025% cream/oint: apply as directed.
Asthma prophylaxis. Initial: 600-800 mcg/day. Maintenance: 400 mcg/day in divided doses.
Severe asthma 250 mcg 4 times/day. Max: 2 mg/day.
Nasal allergic and non-allergic rhinitis 100 mcg into each nostril twice daily. Max: 400 mcg/day.
Indications in palliative care: reversible and irreversible airways obstruction, stridor, lymphangitis carcinomatosa, radiation pneumonitis, cough after insertion of bronchial stent.