Is a rare syndrome that occurs alone or with other neurologic disorders.
It is usually associated with various cancers; it may occur before or after the diagnosis of cancer.
Patients present a subacute onset of intestinal dysmotility characterized by chronic nausea and anorexia secondary to gastroparesis with delayed gastric emptying, marked small and large intestinal dilatation and poor propulsive activity , and sometimes symptoms and signs consistent with intestinal pseudo-obstruction.
Other manifestations associated with neuropatic and autonomic disorders are cardiovascular alterations (postural hypotension, syncopal episodes, painless myocardial infarction, and fixed heart rate), pupillary abnormalities, sensory disturbances, and neurogenic bladder.
Ripamonti C and Rodriguez C. Autonomic neuropathy. Topics in palliative care. Volume 1. New York. Oxford University Press. 1997. Pages 75-77.